Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 14/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498763 | 0.76 | FGFR1 (0.53) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| SCHEMBL14724660 | 0.75 | BRAF (0.42) | EGFRBRAF | |
| SCHEMBL5496280 | 0.72 | LMNA (0.44) | BRAFKDM4EALDH1A1 | |
| SCHEMBL14568928 | 0.70 | FGFR1 (0.63) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| SCHEMBL14569051 | 0.70 | FGFR1 (0.57) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| SCHEMBL14568927 | 0.70 | FGFR1 (0.63) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| SCHEMBL5495483 | 0.69 | BRAF (0.43) | BRAFALDH1A1 | |
| SCHEMBL27873830 | 0.69 | EGFR (0.47) | EGFR | |
| SCHEMBL14568935 | 0.67 | FGFR1 (0.54) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| SCHEMBL14724690 | 0.67 | LCK (0.39) | EGFRBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |