Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | DNM2 | P50570 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14568526 | 0.84 | BRAF (0.43) | BRAFEGFRMKNK1DNM2MKNK2 | |
| SCHEMBL5505032 | 0.83 | EGFR (0.53) | BRAFEGFRMKNK1DNM2MKNK2 | |
| SCHEMBL3337103 | 0.79 | FDPS (0.53) | EGFRMKNK1DNM2MKNK2NCF1 | |
| SCHEMBL14724690 | 0.77 | LCK (0.39) | BRAFEGFR | |
| SCHEMBL12633603 | 0.76 | CYP2C19 (0.43) | EGFRMKNK1DNM2HRH3CYP2C19 | |
| SCHEMBL5495588 | 0.75 | FLT3 (0.47) | EGFR | |
| SCHEMBL14724559 | 0.75 | LCK (0.44) | BRAFMKNK1HRH3 | |
| SCHEMBL14724653 | 0.75 | FGFR1 (0.42) | BRAFEGFR | |
| SCHEMBL14724662 | 0.73 | LCK (0.53) | EGFRMKNK1SYK | |
| SCHEMBL29924736 | 0.70 | CYP2C19 (0.49) | EGFRMKNK1DNM2MKNK2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |