Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2747272 | 0.84 | MEN1 (0.48) | KMT2AMEN1ALDH1A1HTTHPGD | |
| SCHEMBL16097376 | 0.84 | MEN1 (0.51) | KMT2AMEN1ALDH1A1HTTHPGD | |
| SCHEMBL2748284 | 0.82 | LMNA (0.50) | KMT2AMEN1ALDH1A1HTTHPGD | |
| SCHEMBL520594 | 0.81 | SMN1; SMN2 (0.54) | KMT2AMEN1ALDH1A1HTTHPGD | |
| SCHEMBL3147738 | 0.78 | ALDH1A1 (0.65) | KMT2AMEN1ALDH1A1HTTGAA | |
| SCHEMBL5742669 | 0.78 | MEN1 (0.43) | KMT2AMEN1ALDH1A1HTTHPGD | |
| SCHEMBL4551336 | 0.77 | ALDH1A1 (0.64) | KMT2AMEN1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL5742478 | 0.77 | LMNA (0.48) | KMT2AMEN1ALDH1A1HTTHPGD | |
| SCHEMBL5497669 | 0.76 | KMT2A (0.54) | KMT2AMEN1ALDH1A1HTTHPGD | |
| SCHEMBL3147066 | 0.76 | KMT2A (0.67) | KMT2AMEN1ALDH1A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |