Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.59 |
| ▸ | MET | P08581 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13202487 | 0.91 | EPHX2 (0.56) | EPHX2METKDM4EL3MBTL1THRB | |
| SCHEMBL5494307 | 0.80 | LCK (0.61) | — | |
| SCHEMBL13202486 | 0.80 | HRH3 (0.58) | KDM4E | |
| SCHEMBL4501680 | 0.79 | HRH3 (0.56) | EPHX2MET | |
| SCHEMBL5689390 | 0.78 | MET (0.50) | EPHX2METKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL21296732 | 0.76 | TLR9 (0.57) | EPHX2METESR1 | |
| SCHEMBL25059606 | 0.76 | KDM4E (0.67) | KDM4EL3MBTL1 | |
| SCHEMBL20303825 | 0.75 | KDM4E (0.63) | METKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL2089343 | 0.74 | KDM4E (0.68) | KDM4EL3MBTL1ALDH1A1KMT2AESR1 | |
| SCHEMBL19321863 | 0.74 | CYP2D6 (0.67) | KDM4EL3MBTL1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |