Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | MET | P08581 | 10/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14724684 | 0.79 | EPHX2 (0.59) | METEPHX2 | |
| SCHEMBL4498809 | 0.79 | HRH3 (0.64) | HRH3 | |
| SCHEMBL4505460 | 0.77 | HRH3 (0.68) | HRH3 | |
| SCHEMBL13202487 | 0.77 | EPHX2 (0.56) | METTLR9EPHX2 | |
| SCHEMBL4496358 | 0.76 | HRH3 (0.72) | HRH3 | |
| SCHEMBL4506398 | 0.76 | HRH3 (0.65) | HRH3 | |
| SCHEMBL4509190 | 0.75 | HRH3 (0.64) | HRH3 | |
| SCHEMBL4499048 | 0.75 | HRH3 (0.64) | HRH3 | |
| SCHEMBL4969245 | 0.74 | MCHR1 (0.70) | HRH3 | |
| SCHEMBL4502549 | 0.74 | HRH3 (0.67) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608617-B2 | Naphthaline derivatives as H3 inverse agonists | HOFFMANN-LA ROCHE INC. (US) | 2009-10-27 | — | — | US | disclosed |