Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717327 | 0.86 | METAP2 (0.35) | POLBPTPN1 | |
| SCHEMBL1648544 | 0.86 | METAP2 (0.35) | POLBPTPN1 | |
| SCHEMBL1649278 | 0.85 | ALDH1A1 (0.34) | POLBCNKSR1LY96PTPN1 | |
| SCHEMBL14725743 | 0.85 | ALDH1A1 (0.34) | POLBCNKSR1LY96PTPN1 | |
| SCHEMBL1648308 | 0.85 | ALDH1A1 (0.34) | POLBCNKSR1LY96PTPN1 | |
| SCHEMBL14725639 | 0.82 | PLCG1 (0.46) | POLBCYP1A2CYP2C19NQO2 | |
| SCHEMBL1648539 | 0.74 | METAP2 (0.47) | — | |
| SCHEMBL14718068 | 0.74 | METAP2 (0.47) | — | |
| SCHEMBL14717297 | 0.73 | METAP2 (0.48) | — | |
| SCHEMBL14717298 | 0.73 | METAP2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067905-B2 | Sulphone compounds and methods of making and using same | ZAFGEN, INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-20130053364-A1 | Sulphone Compounds and Methods of Making and Using Same | ZAFGEN, INC. | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053364-A1 | Sulphone Compounds and Methods of Making and Using Same | METAP2, DNPEP, STS | POLB 3162/4885CNKSR1 4756/4885CYP1A2 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.