SCHEMBL14725772

SCHEMBL14725772

c1ccc2c(c1)oc1c(-c3cc4cc5c(cc(-c6cccc7c6oc6ccccc67)c6c5ccc5c7ccccc7sc56)cc4c4ccc5c6ccccc6sc5c34)cccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 3/20 0.44
PRKDC P78527 11/20 0.40
PIK3CD O00329 3/20 0.40
PIK3CB P42338 3/20 0.40
BRDT Q58F21 2/20 0.40
BRD4 O60885 1/20 0.40
PIK3CA P42336 1/20 0.40
MTOR P42345 1/20 0.40
PIK3CG P48736 1/20 0.40
KCNH2 Q12809 1/20 0.40
ESR2 Q92731 2/20 0.38
ESR1 P03372 1/20 0.36
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
CASP1 P29466 1/20 0.34
HIF1A Q16665 1/20 0.34
HSD17B10 Q99714 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14725744 0.93 ALOX5 (0.40) ALOX5PRKDCPIK3CDPIK3CBBRDT
SCHEMBL14725670 0.90 ALOX5 (0.44) ALOX5PRKDCPIK3CDPIK3CBBRDT
SCHEMBL14725739 0.87 ALOX5 (0.52) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL14883050 0.87 ALOX5 (0.43) ALOX5PRKDCPIK3CDPIK3CBBRDT
SCHEMBL14725677 0.85 ALOX5 (0.40) ALOX5PRKDCPIK3CDPIK3CBBRDT
SCHEMBL19803007 0.83 PRKDC (0.50) ALOX5PRKDCPIK3CDPIK3CBBRDT
SCHEMBL14725767 0.83 ALOX5 (0.49) ALOX5PRKDCPIK3CDPIK3CBBRDT
SCHEMBL14882922 0.82 PRKDC (0.40) ALOX5PRKDCPIK3CDPIK3CBBRDT
SCHEMBL17299623 0.82 ESR2 (0.41) ALOX5PRKDCPIK3CDPIK3CBESR2
SCHEMBL21583609 0.82 PRKDC (0.49) ALOX5PRKDCPIK3CDPIK3CBBRDT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9255084-B2 Heterocyclic compound and organic light-emitting device containing the same SAMSUNG DISPLAY CO., LTD. (KR) 2016-02-09 US disclosed
US-20130048955-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CONTAINING THE SAME SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2013-02-28 US disclosed
US-20130048955-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CONTAINING THE SAME SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2013-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130048955-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CONTAINING THE SAME TRPC1, TRPC4, TRPC6 ALOX5 648/4885PRKDC 4431/4885PIK3CD 1227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.