Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.45 |
| ▸ | HPN | P05981 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SDCBP | O00560 | 1/20 | 0.41 |
| ▸ | SDC2 | P34741 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30336902 | 0.83 | HDAC1 (0.48) | GRM2HDAC1L3MBTL1HPGDNAMPT | |
| SCHEMBL23997244 | 0.83 | HDAC1 (0.48) | GRM2HDAC1L3MBTL1HPGDNAMPT | |
| SCHEMBL18664525 | 0.83 | GRM2 (0.57) | GRM2HDAC1L3MBTL1HPGDFAAH | |
| SCHEMBL13146715 | 0.83 | GRM2 (0.44) | GRM2HDAC1L3MBTL1CA1CA2 | |
| SCHEMBL14726491 | 0.82 | GRM2 (0.51) | GRM2HDAC1HPNL3MBTL1HPGD | |
| SCHEMBL1444314 | 0.82 | HPGD (0.59) | GRM2L3MBTL1HPGDFAAHNAMPT | |
| SCHEMBL14718500 | 0.81 | HTT (0.43) | HDAC1HPGDHDAC2HDAC3HDAC6 | |
| Hydrochloric Acid SCHEMBL27698235 | 0.80 | HPGD (0.58) | GRM2L3MBTL1HPGDFAAHNAMPT | |
| SCHEMBL31738223 | 0.80 | GRM2 (0.49) | GRM2HDAC1L3MBTL1NAMPTCA1 | |
| SCHEMBL2443309 | 0.80 | GRM2 (0.44) | GRM2HDAC1L3MBTL1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053382-A1 | Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1) | PALIWAL SUNIL (US) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053382-A1 | Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1) | PDK1, PDPK1, PDK3 | GRM2 2543/4885HDAC1 203/4885HPN 2610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.