Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16954214 | 0.87 | SIRT6 (0.44) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL14722272 | 0.87 | ALDH5A1 (0.55) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2390718 | 0.85 | SIRT6 (0.46) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL15894148 | 0.83 | MEN1 (0.54) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL14721537 | 0.83 | MEN1 (0.54) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL14721536 | 0.83 | MEN1 (0.54) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL28450330 | 0.81 | MEN1 (0.44) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL1318248 | 0.80 | ABCB1 (0.47) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL23044890 | 0.79 | HTT (0.49) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL13236063 | 0.79 | MAPT (0.53) | MEN1KMT2AALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026931-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-02-28 | — | — | WO | disclosed |