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Sugi Predict / Targets / ALDH5A1

ALDH5A1

Succinate-semialdehyde dehydrogenase, mitochondrial · P51649 · ALDH5A1 on Sugi Atlas →

8,898 patent compounds predicted against ALDH5A1, 6,823 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1012820 SCHEMBL1012820 0.67 3/20
Protocatechualdehyde Protocatechualdehyde (SCHEMBL36350) 0.57 3/20
SCHEMBL142988 SCHEMBL142988 0.57 3/20
SCHEMBL79952 SCHEMBL79952 0.52 3/20
SCHEMBL111227 SCHEMBL111227 0.52 3/20
SCHEMBL115626 SCHEMBL115626 0.52 3/20
SCHEMBL151496 SCHEMBL151496 0.52 3/20
SCHEMBL190410 SCHEMBL190410 0.52 3/20
SCHEMBL219109 SCHEMBL219109 0.52 3/20
SCHEMBL856316 SCHEMBL856316 0.47 3/20
SCHEMBL430962 SCHEMBL430962 0.47 3/20
SCHEMBL545072 SCHEMBL545072 0.47 3/20
SCHEMBL476028 SCHEMBL476028 0.42 3/20
SCHEMBL881431 SCHEMBL881431 0.40 3/20
SCHEMBL283036 SCHEMBL283036 0.38 3/20
SCHEMBL1245777 SCHEMBL1245777 0.34 3/20
SCHEMBL361345 SCHEMBL361345 0.62 2/20
SCHEMBL856737 SCHEMBL856737 0.61 2/20
SCHEMBL359491 SCHEMBL359491 0.59 2/20
SCHEMBL658295 SCHEMBL658295 0.58 2/20

Clinical trials — most relevant to ALDH5A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: PHASE3ACTIVE_NOT_RECRUITING
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST PHASE2COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) PHASE1/PHASE2NOT_YET_RECRUITING
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC PHASE1/PHASE2UNKNOWN
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients nanRECRUITING
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Fasting Tolerance in MCADD-infants nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion nanNOT_YET_RECRUITING
Longitudinal Study of Mitochondrial Hepatopathies nanSUSPENDED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies nanRECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN
Diagnostic Odyssey Survey 2 nanCOMPLETED
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN) nanUNKNOWN
Study of Protein Translocation in Patients With Beta-Oxidation Disorders nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
Effects of Parenteral L-carnitine Supplementation in Premature Neonates nanCOMPLETED
Prospective Observational Study of Trimetazidine Influence on Mitochondrial Metabolism in Human Heart Ventricle nanCOMPLETED
Effect of Diaphragm Stimulation During Surgery nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a ALDH5A1 binder may also engage these)

ProteinNameSimilarity
Q6A2H0 — 1.000 Q6A2H0 →
Q6A2H1 — 1.000 Q6A2H1 →
Q3MSM4 — 1.000 Q3MSM4 →
Q3MSM3 — 1.000 Q3MSM3 →
Q6A2H2 — 1.000 Q6A2H2 →
Q8BWF0 — 1.000 Q8BWF0 →
P51650 — 0.995 P51650 →
Q19A30 — 0.995 Q19A30 →
Q2XQV4 — 0.993 Q2XQV4 →
Q802W2 — 0.992 Q802W2 →
Q9SAK4 — 0.990 Q9SAK4 →
Q84LK3 — 0.989 Q84LK3 →
Q9SU63 — 0.989 Q9SU63 →
P56533 — 0.988 P56533 →
ALDH1A3 Retinaldehyde dehydrogenase 3 0.987 landscape →
B9F3B6 — 0.987 B9F3B6 →
Q9JLJ3 — 0.987 Q9JLJ3 →
Q9CZS1 — 0.986 Q9CZS1 →
P47738 — 0.986 P47738 →
P11884 — 0.986 P11884 →
ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 0.986 landscape →
P81178 — 0.985 P81178 →
Q5RF00 — 0.985 Q5RF00 →
P49189 — 0.985 P49189 →
Q9JHW9 — 0.984 Q9JHW9 →
Q25417 — 0.984 Q25417 →
C6KEM4 — 0.984 C6KEM4 →
Q02252 — 0.983 Q02252 →
P51977 — 0.983 P51977 →
P55653 — 0.983 P55653 →