SCHEMBL14729121

SCHEMBL14729121

COc1cccc(Oc2ccc3c(c2)C(=O)N(c2cccc(N4C(=O)c5ccc(C)cc5C4=O)c2)C3=O)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.59
KMT2A Q03164 7/20 0.59
BRD4 O60885 1/20 0.57
ALDH1A1 P00352 5/20 0.55
MAPT P10636 2/20 0.55
SMN1; SMN2 Q16637 3/20 0.53
HPGD P15428 1/20 0.53
POLB P06746 1/20 0.49
MAPK1 P28482 1/20 0.49
HTT P42858 2/20 0.49
LMNA P02545 1/20 0.49
RAB9A P51151 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
GAA P10253 2/20 0.48
ESR1 P03372 1/20 0.47
MGLL Q99685 1/20 0.47
LPAR1 Q92633 1/20 0.46
LPAR5 Q9H1C0 1/20 0.46
LPAR3 Q9UBY5 1/20 0.46
MCHR1 Q99705 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16706899 0.94 MEN1 (0.60) MEN1KMT2ABRD4ALDH1A1MAPT
SCHEMBL14729123 0.94 MEN1 (0.57) MEN1KMT2ABRD4ALDH1A1MAPT
SCHEMBL14731789 0.88 MEN1 (0.61) MEN1KMT2ABRD4ALDH1A1MAPT
SCHEMBL15905656 0.88 BRD4 (0.57) MEN1KMT2ABRD4ALDH1A1MAPT
SCHEMBL13899363 0.87 ALDH1A1 (0.62) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL12154350 0.86 MEN1 (0.53) MEN1KMT2ABRD4ALDH1A1MAPT
SCHEMBL14729118 0.86 MEN1 (0.58) MEN1KMT2ABRD4ALDH1A1MAPT
SCHEMBL12662554 0.86 MEN1 (0.50) MEN1KMT2ABRD4ALDH1A1MAPT
SCHEMBL13899508 0.85 MEN1 (0.59) MEN1KMT2ABRD4ALDH1A1MAPT
SCHEMBL18312046 0.85 MEN1 (0.52) MEN1KMT2ABRD4ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170260333-A1 POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2017-09-14 US disclosed
US-9688816-B2 Polyetherimide compositions and methods for the manufacture and use thereof SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2017-06-27 US disclosed
US-20130053489-A1 POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2013-02-28 US disclosed