Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730173 | 0.95 | PDK2 (0.34) | PDK2NR1H2NR1H3EIF2AK4 | |
| SCHEMBL14730174 | 0.95 | PDK2 (0.33) | GPR119PDK2NR1H2NR1H3EIF2AK4 | |
| SCHEMBL14730168 | 0.93 | GPR119 (0.36) | GPR119KCNH2NR1H2NR1H3CYP3A4 | |
| SCHEMBL14730273 | 0.92 | GPR119 (0.35) | GPR119KCNH2NR1H2NR1H3CYP3A4 | |
| SCHEMBL14730327 | 0.92 | GPR119 (0.35) | GPR119PDK2KCNH2NR1H2NR1H3 | |
| SCHEMBL14730219 | 0.91 | PDK2 (0.36) | GPR119PDK2NR1H2NR1H3EIF2AK4 | |
| SCHEMBL14730259 | 0.91 | PDK2 (0.36) | GPR119PDK2KCNH2NR1H2NR1H3 | |
| SCHEMBL14730325 | 0.89 | NTRK1 (0.33) | GPR119NR1H2NR1H3MAPTEIF2AK4 | |
| SCHEMBL14730255 | 0.88 | PDK2 (0.34) | PDK2 | |
| SCHEMBL14730209 | 0.87 | GPR119 (0.31) | GPR119NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |