Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730318 | 0.94 | NTRK1 (0.34) | NR1H2GPR119HDAC4HDAC6KCNH2 | |
| SCHEMBL14730268 | 0.93 | GPR119 (0.35) | NR1H2GPR119SYKHDAC4HDAC6 | |
| SCHEMBL14730257 | 0.92 | GPR119 (0.32) | PDK2GPR119HDAC4HDAC6KCNH2 | |
| SCHEMBL14730256 | 0.92 | PDK2 (0.34) | PDK2NR1H2GPR119SYKHDAC4 | |
| SCHEMBL14730219 | 0.92 | PDK2 (0.36) | PDK2NR1H2GPR119SYKHDAC4 | |
| SCHEMBL14730173 | 0.91 | PDK2 (0.34) | PDK2NR1H2SYKEIF2AK4NR1H3 | |
| SCHEMBL14730217 | 0.91 | GPR119 (0.34) | PDK2NR1H2GPR119KCNH2EIF2AK4 | |
| SCHEMBL14730212 | 0.90 | NTRK1 (0.33) | NR1H2GPR119HDAC4HDAC6KCNH2 | |
| SCHEMBL14730174 | 0.89 | PDK2 (0.33) | PDK2NR1H2GPR119EIF2AK4NR1H3 | |
| SCHEMBL14730255 | 0.88 | PDK2 (0.34) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |