Sugi Predict

Sugi Predict / Compounds / SCHEMBL14730302

SCHEMBL14730302

SCHEMBL14730302

C=C/C(F)=C(F)\C=C(\F)C[C@H]1CN(c2ncc(C(=O)N(C)C3CCN(c4nc(C(C)(F)F)no4)CC3)cn2)C[C@@H]1N

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ ALOX5AP P20292 4/20 0.33
▸ GPR119 Q8TDV5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14730298 0.91 ALOX5AP (0.34) ALOX5APGPR119
SCHEMBL14730368 0.91 GPR119 (0.32) GPR119
SCHEMBL14730246 0.89 GPR119 (0.32) GPR119
SCHEMBL14730300 0.89 GPR119 (0.35) GPR119
SCHEMBL14730182 0.89 GPR119 (0.35) GPR119
SCHEMBL14730192 0.83 GPR119 (0.32) ALOX5APGPR119
SCHEMBL14730233 0.83 GPR119 (0.32) ALOX5APGPR119
SCHEMBL14730169 0.81 GPR119 (0.33) GPR119
SCHEMBL14730245 0.81 GPR119 (0.32) GPR119
SCHEMBL14730170 0.79 GPR119 (0.30) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013026587-A1 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2013-02-28 — — WO disclosed