Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 5/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CCND2 | P30279 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12727726 | 0.87 | CDK4 (0.39) | CDK4ACVR1CCND1CDK1CCNB1 | |
| SCHEMBL12162446 | 0.86 | JAK3 (0.40) | CDK4CCND1CDK1CCNB1FLT3 | |
| SCHEMBL1115176 | 0.86 | JAK3 (0.40) | CDK4CCND1CDK1CCNB1FLT3 | |
| SCHEMBL12727791 | 0.85 | CDK4 (0.50) | CDK4CCND1CDK1CCNB1CDK6 | |
| SCHEMBL12727723 | 0.84 | CDK4 (0.53) | CDK4CCND1CDK1CCNB1FLT3 | |
| SCHEMBL1115163 | 0.84 | CDK4 (0.53) | CDK4CCND1CDK1CCNB1FLT3 | |
| SCHEMBL12727722 | 0.78 | CDK2 (0.45) | CDK4ACVR1CCND1CDK1CCNB1 | |
| SCHEMBL1115502 | 0.78 | CDK2 (0.45) | CDK4ACVR1CCND1CDK1CCNB1 | |
| SCHEMBL15875549 | 0.76 | CDK4 (0.47) | CDK4CCND1CDK1CCNB1FLT3 | |
| SCHEMBL2565742 | 0.76 | CDK4 (0.42) | CDK4CCND1CDK1CCNB1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389533-B2 | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors | AMGEN INC. (US) | 2013-03-05 | — | — | US | claimed |