Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 12/20 | 1.00 |
| ▸ | SRPK1 | Q96SB4 | 6/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | SRPK2 | P78362 | 5/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14733010 | 0.85 | PTK2 (1.00) | PTK2SRPK1 | |
| SCHEMBL14733022 | 0.82 | PTK2 (1.00) | PTK2SRPK1 | |
| SCHEMBL14733020 | 0.79 | PTK2 (1.00) | PTK2SRPK1SRPK2 | |
| SCHEMBL16967461 | 0.78 | PTK2 (1.00) | PTK2SRPK1SRPK2SRPK3 | |
| SCHEMBL12586298 | 0.74 | PTK2 (0.58) | PTK2SRPK1SRPK2SRPK3 | |
| SCHEMBL407224 | 0.73 | PTK2 (0.57) | PTK2SRPK1SRPK2SRPK3 | |
| SCHEMBL12887591 | 0.72 | PTK2 (0.58) | PTK2SRPK1SRPK2SRPK3 | |
| SCHEMBL11987598 | 0.71 | PTK2 (0.55) | PTK2SRPK1SRPK2SRPK3 | |
| SCHEMBL10229210 | 0.71 | PTK2 (0.53) | PTK2SRPK1SRPK2SRPK3 | |
| SCHEMBL721543 | 0.71 | PTK2 (0.55) | PTK2SRPK1SRPK2SRPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | claimed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | claimed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| WO-2013026516-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | CDK1, CDK2, CDK4 | PTK2 1291/4885SRPK1 483/4885JAK2 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.