Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 18/20 | 1.00 |
| ▸ | CLK2 | P49760 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14733008 | 0.85 | PTK2 (1.00) | PTK2SRPK1 | |
| SCHEMBL14733097 | 0.83 | PTK2 (1.00) | PTK2SRPK1 | |
| SCHEMBL14733022 | 0.82 | PTK2 (1.00) | PTK2SRPK1 | |
| SCHEMBL14733020 | 0.79 | PTK2 (1.00) | PTK2SRPK1 | |
| SCHEMBL12586298 | 0.74 | PTK2 (0.58) | PTK2PTK2BSRPK1 | |
| SCHEMBL17971184 | 0.73 | PTK2 (0.58) | PTK2PTK2BSRPK1 | |
| SCHEMBL13055175 | 0.72 | PTK2 (0.57) | PTK2PTK2BSRPK1 | |
| SCHEMBL29051725 | 0.72 | PTK2 (0.58) | PTK2PTK2BSRPK1 | |
| SCHEMBL408023 | 0.71 | PTK2 (0.54) | PTK2PTK2BSRPK1 | |
| SCHEMBL11987598 | 0.71 | PTK2 (0.55) | PTK2PTK2BSRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | claimed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | claimed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| WO-2013026516-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | CDK1, CDK2, CDK4 | PTK2 1291/4885CLK2 207/4885AURKB 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.