Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | ROS1 | P08922 | 3/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | HEXA | P06865 | 1/20 | 0.35 |
| ▸ | HEXB | P07686 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 3/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774043 | 0.89 | NTRK1 (0.36) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL441643 | 0.87 | RHEB (0.40) | RHEBMEN1NPC1RAB9AKMT2A | |
| SCHEMBL441181 | 0.86 | NTRK1 (0.35) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL439680 | 0.83 | NTRK1 (0.61) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL773567 | 0.83 | CARM1 (0.36) | NTRK1ACVRL1RETROS1MET | |
| Hydrochloric Acid SCHEMBL3469036 | 0.82 | NTRK1 (0.60) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL1350206 | 0.82 | CARM1 (0.36) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL441580 | 0.82 | PRKAG1 (0.36) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL450332 | 0.82 | PRKAG1 (0.36) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL450185 | 0.82 | RHEB (0.37) | NTRK1ACVRL1RETROS1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815906-B2 | Tyrosine kinase inhibitors | CHEMBRIDGE CORPORATION (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130053376-A1 | NOVEL TYROSINE KINASE INHIBITORS | CHEMBRIDGE COPRPORATION | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053376-A1 | NOVEL TYROSINE KINASE INHIBITORS | ABL1, RET, TTBK1 | NTRK1 331/4885ACVRL1 1949/4885RET 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.