Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CBFB | Q13951 | 2/20 | 0.35 |
| ▸ | RHEB | Q15382 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441580 | 1.00 | PRKAG1 (0.36) | PRKAG1PRKAA1PRKAB1KMT2ARAB9A | |
| SCHEMBL441643 | 0.84 | RHEB (0.40) | PRKAG1PRKAA1PRKAB1KMT2ARAB9A | |
| SCHEMBL774043 | 0.83 | NTRK1 (0.36) | PRKAG1PRKAA1PRKAB1KMT2ARAB9A | |
| SCHEMBL773555 | 0.83 | PRKAG1 (0.38) | PRKAG1PRKAA1PRKAB1KMT2ARAB9A | |
| SCHEMBL441258 | 0.82 | NTRK1 (0.43) | RAB9ARHEBNPC1NTRK1ACVRL1 | |
| SCHEMBL452940 | 0.82 | NTRK1 (0.43) | RAB9ARHEBNPC1NTRK1ACVRL1 | |
| SCHEMBL450185 | 0.82 | RHEB (0.37) | PRKAG1PRKAA1PRKAB1KMT2ARAB9A | |
| SCHEMBL14733128 | 0.82 | NTRK1 (0.46) | PRKAG1PRKAA1PRKAB1KMT2ARAB9A | |
| SCHEMBL1350206 | 0.79 | CARM1 (0.36) | PRKAG1PRKAA1PRKAB1RHEBNTRK1 | |
| SCHEMBL441275 | 0.79 | RHEB (0.40) | PRKAG1PRKAA1PRKAB1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273055-B2 | Tyrosine kinase inhibitors | CHEMBRIDGE CORPORATION (US) | 2016-03-01 | — | — | US | disclosed |
| US-20150038536-A1 | TYROSINE KINASE INHIBITORS | CHEMBRIDGE COPRPORATION | 2015-02-05 | — | — | US | disclosed |
| US-8822500-B2 | Tyrosine kinase inhibitors | CHEMBRIDGE CORPORATION (US) | 2014-09-02 | — | — | US | disclosed |
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | GREGOR VLAD EDWARD (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038536-A1 | TYROSINE KINASE INHIBITORS | ALK, ROS1, ABL1 | PRKAG1 250/4885PRKAA1 49/4885PRKAB1 315/4885 |
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | ALK, ROS1, ABL1 | PRKAG1 250/4885PRKAA1 49/4885PRKAB1 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.