Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16079017 | 0.78 | PSMB8 (0.51) | MDM4PSMB8ADORA2AADORA1KDM4E | |
| SCHEMBL23087502 | 0.66 | SLC22A12 (0.35) | MDM4ADORA2AADORA1PIM1ALDH1A1 | |
| SCHEMBL5679618 | 0.62 | SCN4A (0.42) | ALDH1A1 | |
| SCHEMBL15927564 | 0.60 | PSMB8 (0.42) | PSMB8 | |
| SCHEMBL31275849 | 0.59 | UBE2T (0.66) | KDM4EALDH1A1 | |
| SCHEMBL20076959 | 0.58 | KDM4E (0.38) | MDM4ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL3984419 | 0.58 | MAPT (0.59) | MDM4KDM4EALDH1A1 | |
| SCHEMBL21063750 | 0.58 | PSMB8 (0.65) | PSMB8ADORA2AKDM4EALDH1A1 | |
| SCHEMBL1398115 | 0.57 | ALDH1A1 (0.43) | MDM4ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL20972654 | 0.56 | MEN1 (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026806-A1 | DYRK1 INHIBITORS AND USES THEREOF | EXONHIT SA (FR) | 2013-02-28 | — | — | WO | disclosed |