Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Procyclidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 9/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 9/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 7/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 6/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 5/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 3/20 | 1.00 |
| ▸ | HRH1 | P35367 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 1/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 1/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 1/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 1/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 1/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 1/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trihexyphenidyl SCHEMBL1320615 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| (R)-Procyclidine SCHEMBL15305878 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Cycrimine SCHEMBL249004 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL34646 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Cycrimine SCHEMBL249005 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL34645 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| (S)-Procyclidine SCHEMBL519431 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Procyclidine SCHEMBL121684 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL42410 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL30061697 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5831 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-20260091047-A1 | THERAPEUTIC COMBINATIONS FOR MOVEMENT DISORDERS | NATIVE CODE BIO LLC (US) | 2026-04-02 | — | — | US | claimed |
| EP-4717276-A2 | OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER | University of Canberra (AU) | 2026-04-01 | — | — | EP | claimed |
| EP-4706766-A2 | TOPICAL OPHTHALMOLOGICAL COMPOSITIONS | ADS Therapeutics LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-12485177-B2 | Topical ophthalmological compositions | ADS THERAPEUTICS LLC (US) | 2025-12-02 | — | — | US | claimed |
| EP-3442516-B1 | OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER | UNIV CANBERRA (AU) | 2025-11-12 | — | — | EP | claimed |
| US-20250302814-A1 | METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA | APNIMED, INC. (DELAWARE) | 2025-10-02 | — | — | US | claimed |
| EP-4154879-B1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NICOTINE WITHDRAWAL SYMPTOMS | KOREA INST SCI & TECH (KR) | 2025-09-10 | — | — | EP | claimed |
| US-20250241933-A1 | METHODS OF TREATING SLEEP APNEA WITH A COMBINATION OF A CANNABINOID AND A CARBONIC ANHYDRASE INHIBITOR | APNIMED, INC. (DELAWARE) | 2025-07-31 | — | — | US | claimed |
| EP-0432994-A2 | Excitatory amino acid antagonists as anti-emetic drugs | Olney, John William (US) | 1991-06-19 | — | — | EP | claimed |
| EP-0424179-A2 | Use of combined excitatory amino acid and cholinergic antagonists to prevent neurological deterioration | Olney, John William (US) | 1991-04-24 | — | — | EP | claimed |
| US-5008111-A | Pretreating skin with anticholinergic quaternary ammonium salt to suppress perspiration | SCHERING CORPORATION (US) | 1991-04-16 | — | — | US | claimed |
| EP-0414568-A2 | Use of anticholinergic compounds for protecting the central nervous system against cholinergic neurotoxins | WASHINGTON UNIVERSITY (US) | 1991-02-27 | — | — | EP | claimed |
| US-4988710-A | Anticonvulsants, anticholinergic agents, aryl-cycloalkanolamines | WASHINGTON UNIVERSITY (US) | 1991-01-29 | — | — | US | claimed |
| US-4945097-A | THERAPY FOR ANOXIA, HYPOXIA, OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1990-07-31 | — | — | US | claimed |
| US-4824676-A | ANTICHOLINERGIC AGENT TO SUPPRESS PERSPIRATION | SCHERING CORPORATION (US) | 1989-04-25 | — | — | US | claimed |
| US-4546096-A | Anticholinergic glucuronides and antiperspirant use thereof | REPLIGEN CORPORATION (US) | 1985-10-08 | — | — | US | claimed |
| EP-0154446-A2 | Anti-cholinergic glucuronides and their anti-perspirant use | REPLIGEN CORPORATION (US) | 1985-09-11 | — | — | EP | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |