Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (S)-Procyclidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 9/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 9/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 7/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 6/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 5/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 3/20 | 1.00 |
| ▸ | HRH1 | P35367 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 1/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 1/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 1/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 1/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 1/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 1/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trihexyphenidyl SCHEMBL1320615 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| (R)-Procyclidine SCHEMBL15305878 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Cycrimine SCHEMBL249004 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL34646 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Cycrimine SCHEMBL249005 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL34645 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Procyclidine SCHEMBL147344 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Procyclidine SCHEMBL121684 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL42410 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL30061697 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 375 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024249914-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING DYSTONIA | DUKE UNIVERSITY (US) | 2024-12-05 | — | — | WO | claimed |
| US-20170224911-A1 | BIOSYNCHRONOUS TRANSDERMAL DRUG DELIVERY FOR LONGEVITY, ANTI-AGING, FATIGUE MANAGEMENT, OBESITY, WEIGHT LOSS, WEIGHT MANAGEMENT, DELIVERY OF NUTRACEUTICALS, AND THE TREATMENT OF HYPERGLYCEMIA, ALZHEIMER'S DISEASE, SLEEP DISORDERS, PARKINSON'S DISEASE, AIDS, EPILEPSY, ATTENTION DEFICIT DISORDER, NICOTINE ADDICTION, CANCER, HEADACHE AND PAIN CONTROL, ASTHMA, ANGINA, HYPERTENSION, DEPRESSION, COLD, FLU AND THE LIKE | MORNINGSIDE VENTURE INVESTMENTS LIMITED | 2017-08-10 | — | — | US | claimed |
| US-9086091-B2 | Bearing assembly for rock drill | CATERPILLAR GLOBAL MINING EQUIPMENT LLC (US) | 2015-07-21 | — | — | US | claimed |
| US-20140376847-A1 | BEARING ASSEMBLY FOR ROCK DRILL | CATERPILLAR GLOBAL MINING EQUIPMENT LLC | 2014-12-25 | — | — | US | claimed |
| CN-101829328-B | Medicine for treating amphetamine type stimulant dependency and mixed dependency of amphetamine type stimulant dependency and opium | LU ZHENGTANG | 2014-02-12 | — | — | CN | claimed |
| CN-103495172-A | Medicament for treating amphetamine type stimulant dependency and mixed dependency of amphetamine type stimulants and opiates substances | LU ZHENGTANG | 2014-01-08 | — | — | CN | claimed |
| EP-2338881-A1 | Dopamine transporter inhibitors for use in treatment of movement disorders and other CNS indications | Prexa Pharmaceuticals, Inc. (US) | 2011-06-29 | — | — | EP | claimed |
| CN-101829328-A | Medicine for treating amphetamine type stimulant dependency and mixed dependency of amphetamine type stimulant dependency and opium | ZHENGTANG LU | 2010-09-15 | — | — | CN | claimed |
| US-20090069361-A1 | METHODS OF TREATMENT USING (+)- ISOPROPYL 2-METHOXYETHYL 4-(2-CHLORO-3-CYANO-PHENYL)-1, 4-DIHYDRO-2, 6-DIMETHYL-PYRIDINE-3, 5-DICARBOXYLATE | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-03-12 | — | — | US | claimed |
| WO-2008127524-A2 | BIOMARKERS OF VERY RAPID ANTIDEPRESSANT RESPONSE AND OF MECHANISM OF VERY RAPID ANTIDEPRESSANT RESPONSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNINA (US) | 2008-10-23 | — | — | WO | claimed |
| JP-2007512339-A | — | — | 2007-05-17 | — | — | JP | claimed |
| WO-2006091697-A1 | DOPAMINE TRANSPORTER INHIBITORS FOR USE IN TREATMENT OF MOVEMENT DISORDERS AND OTHER CNS INDICATIONS | PSYCHENOMICS, INC. (US) | 2006-08-31 | — | — | WO | claimed |
| EP-1684755-A1 | USE OF (+)-ISOPROPYL 2-METHOXYETHYL 4-(2-CHLORO-3-CYANO-PHENYL)-1,4-DIHYDRO-2,6-DYMETHYL-PYRIDINE-3,5-DICARBOXYLATE IN THE TREATMENT OF MEMORY DISORDERS | Memory Pharmaceutical Corporation (US) | 2006-08-02 | — | — | EP | claimed |
| CN-1259974-C | Drug giving-up medicine made-up by non-thebaica medicines | YONG WEICHANG (CN) | 2006-06-21 | — | — | CN | claimed |
| WO-2005051389-A1 | USING OF (+)-ISOPROPYL 2-METHOXYETHYL 4-(2-CHLORO-3-CYANO-PHENYL)-1,4-DIHYDRO-2,6-DYMETHYL-PYRIDINE-3,5-DICARBOXYLATE IN THE TREATMENT OF MEMORY DISORDERS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-06-09 | — | — | WO | claimed |
| CN-1579551-A | Drug giving-up medicine made-up by non-thebaica medicines | YONG WEICHANG (CN) | 2005-02-16 | — | — | CN | claimed |
| CN-1543337-A | Expandable gastric retention device | ���ո����ɸߵȽ�����ίԱ�������� | 2004-11-03 | — | — | CN | claimed |
| CN-1157201-C | Composite non-opium medicine for dropping drugs | 卢正堂 | 2004-07-14 | — | — | CN | claimed |
| CN-1313108-A | Composite non-opium medicine for dropping drugs | LU ZHENGTANG (CN) | 2001-09-19 | — | — | CN | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |