Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trihexyphenidyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 9/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 9/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 7/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 6/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 5/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 3/20 | 1.00 |
| ▸ | HRH1 | P35367 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 1/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 1/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 1/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 1/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 1/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 1/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trihexyphenidyl SCHEMBL1320615 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| (R)-Procyclidine SCHEMBL15305878 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Cycrimine SCHEMBL249004 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL34646 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Cycrimine SCHEMBL249005 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Procyclidine SCHEMBL147344 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| (S)-Procyclidine SCHEMBL519431 | 1.00 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Procyclidine SCHEMBL121684 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL42410 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Trihexyphenidyl SCHEMBL30061697 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CYP2D6KCNH2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13501 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| WO-2026102000-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISORDERS RELATED TO GLUCOSYLCERAMIDASE BETA 1 DEFICIENCY | VOYAGER THERAPEUTICS, INC. (US) | 2026-05-15 | — | — | WO | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| US-20260124147-A1 | THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING MOVEMENT DISORDERS | Vima Therapeutics, Inc. (US) | 2026-05-07 | — | — | US | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-20260091047-A1 | THERAPEUTIC COMBINATIONS FOR MOVEMENT DISORDERS | NATIVE CODE BIO LLC (US) | 2026-04-02 | — | — | US | claimed |
| EP-4717276-A2 | OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER | University of Canberra (AU) | 2026-04-01 | — | — | EP | claimed |
| US-20260083716-A1 | R-TRIHEXYPHENIDYL FOR TREATMENT OF MOVEMENT DISORDERS | THE CHILDREN'S MERCY HOSPITAL (US) | 2026-03-26 | — | — | US | claimed |
| EP-0424179-A2 | Use of combined excitatory amino acid and cholinergic antagonists to prevent neurological deterioration | Olney, John William (US) | 1991-04-24 | — | — | EP | claimed |
| EP-0414568-A2 | Use of anticholinergic compounds for protecting the central nervous system against cholinergic neurotoxins | WASHINGTON UNIVERSITY (US) | 1991-02-27 | — | — | EP | claimed |
| US-4988710-A | Anticonvulsants, anticholinergic agents, aryl-cycloalkanolamines | WASHINGTON UNIVERSITY (US) | 1991-01-29 | — | — | US | claimed |
| US-4945097-A | THERAPY FOR ANOXIA, HYPOXIA, OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1990-07-31 | — | — | US | claimed |
| US-4788063-A | FATTY ACID, CHOLINERGIC OR ANTICHOLINERGIC AGENT | STATE OF ISRAEL, REPRESENTED BY PRIME MINISTER'S OFFICE ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 1988-11-29 | — | — | US | claimed |
| EP-0152379-A2 | Process for preparing pharmaceutical compositions containing unilamellar liposomes | CIBA-GEIGY AG (CH) | 1985-08-21 | — | — | EP | claimed |
| EP-0022771-A4 | RADIO RECEPTOR ASSAY FOR BENZODIAZEPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS. | US HEALTH (US) | 1981-02-04 | — | — | EP | claimed |
| EP-0022771-A1 | RADIO RECEPTOR ASSAY FOR BENZODIAZEPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS | THE UNITED STATES OF AMERICA, represented by DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1981-01-28 | — | — | EP | claimed |
| WO-1980000750-A1 | RADIO RECEPTOR ASSAY FOR BENZODIZAPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS | US COMMERCE (US) | 1980-04-17 | — | — | WO | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |