Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 4/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL71364 | 0.89 | APOBEC3A (0.46) | APOBEC3AAPOBEC3GNPSR1CTDSP1KDM4E | |
| SCHEMBL67836 | 0.83 | APOBEC3A (0.50) | APOBEC3AAPOBEC3GNPSR1CTDSP1KDM4E | |
| Methylamine SCHEMBL5149607 | 0.79 | APOBEC3A (0.47) | APOBEC3AAPOBEC3GCTDSP1KDM4CGAA | |
| SCHEMBL13651660 | 0.78 | NPSR1 (0.45) | APOBEC3AAPOBEC3GNPSR1KDM4EL3MBTL1 | |
| SCHEMBL12255736 | 0.78 | NPSR1 (0.45) | APOBEC3AAPOBEC3GNPSR1KDM4EL3MBTL1 | |
| SCHEMBL31336867 | 0.76 | KDM4E (0.44) | APOBEC3AAPOBEC3GNPSR1KDM4EL3MBTL1 | |
| SCHEMBL13651652 | 0.76 | NPSR1 (0.43) | APOBEC3AAPOBEC3GNPSR1KDM4EL3MBTL1 | |
| SCHEMBL31336866 | 0.76 | KDM4E (0.44) | APOBEC3AAPOBEC3GNPSR1KDM4EL3MBTL1 | |
| SCHEMBL31336864 | 0.76 | NPSR1 (0.43) | APOBEC3AAPOBEC3GNPSR1KDM4EL3MBTL1 | |
| SCHEMBL19737998 | 0.76 | NPSR1 (0.43) | APOBEC3AAPOBEC3GNPSR1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2753604-B1 | PDE10 MODULATORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| EP-2574607-A1 | PDE10 modulators | F. Hoffmann-La Roche AG (CH) | 2013-04-03 | — | — | EP | disclosed |
| WO-2013034506-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-14 | — | — | WO | disclosed |
| US-20130059833-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059833-A1 | PDE10 MODULATORS | PDE10A, PDE5A, PDE2A | APOBEC3A 4224/4885APOBEC3G 4156/4885NPSR1 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.