Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737949 | 0.89 | SLC6A2 (0.48) | SMN1; SMN2HIF1ASLC6A2TAAR1MAOA | |
| SCHEMBL7653149 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2HIF1AALPIPKMPTGS1 | |
| SCHEMBL803931 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1AALPIPKMPTGS1 | |
| Trifluoroacetic Acid SCHEMBL6894534 | 0.75 | ALPI (0.51) | CPA1ALPIPKMPTGS1XIAP | |
| SCHEMBL529024 | 0.74 | TRPA1 (0.44) | SMN1; SMN2HIF1ACPA1CES1ALPI | |
| Trifluoroacetic Acid SCHEMBL2367354 | 0.74 | ALDH1A1 (0.50) | SLC6A2SLC6A3CTRB1CYP2D6SLC1A3 | |
| Trifluoroacetic Acid SCHEMBL27766342 | 0.74 | ALDH1A1 (0.50) | SLC6A2SLC6A3CTRB1CYP2D6SLC1A3 | |
| SCHEMBL29293841 | 0.74 | TRPA1 (0.47) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Dl-Phenylalanine SCHEMBL16649156 | 0.74 | SLC7A5 (0.81) | CPA1ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL3047281 | 0.74 | SLC7A5 (0.81) | CPA1ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | SYK, ZAP70, JAK1 | SMN1; SMN2 4803/4885HIF1A 2728/4885CPA1 2422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.