Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14739080 | 1.00 | SLC6A4 (0.74) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL14739408 | 1.00 | SLC6A4 (0.74) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL3666071 | 1.00 | SLC6A4 (0.74) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL14739638 | 1.00 | SLC6A4 (0.74) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Hydrochloric Acid SCHEMBL3734710 | 0.98 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL20052872 | 0.85 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL17455406 | 0.85 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL20785724 | 0.71 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL21067278 | 0.71 | PLG (0.63) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL29941308 | 0.71 | PLG (0.63) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507500-B2 | Inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-08-13 | — | — | US | disclosed |
| US-20130059864-A1 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-03-07 | — | — | US | disclosed |