Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.95 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.95 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL709685 | 0.98 | AXL (1.00) | AXLNUDT1MAPK1CDK8PIK3CD | |
| SCHEMBL29523425 | 0.98 | — | — | |
| SCHEMBL17837 | 0.98 | — | — | |
| SCHEMBL27692181 | 0.95 | — | — | |
| SCHEMBL27753650 | 0.95 | AXL (0.95) | AXLNUDT1MAPK1CDK8PIK3CD | |
| Bromide SCHEMBL27394282 | 0.95 | AXL (0.95) | AXLNUDT1MAPK1CDK8PIK3CD | |
| Hydrochloric Acid SCHEMBL27893779 | 0.95 | AXL (0.95) | AXLNUDT1MAPK1CDK8PIK3CD | |
| Ammonia Solution, Strong SCHEMBL27486357 | 0.95 | AXL (0.95) | AXLNUDT1MAPK1CDK8PIK3CD | |
| Potassium SCHEMBL30760557 | 0.95 | AXL (0.95) | AXLNUDT1MAPK1CDK8PIK3CD | |
| Hydrochloric Acid SCHEMBL5325493 | 0.95 | AXL (0.95) | AXLNUDT1MAPK1CDK8PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, IDO1 | AXL 4355/4885NUDT1 2012/4885MAPK1 3902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.