Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL29612 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2TET2TET3TET1TP53 | |
| Malic Acid SCHEMBL14740583 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28238524 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2TET2TET3TET1TP53 | |
| Malic Acid SCHEMBL18939741 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL25375751 | 0.81 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1TP53 | |
| Malic Acid SCHEMBL4435950 | 0.81 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1TP53 | |
| Malic Acid SCHEMBL15441377 | 0.81 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1TP53 | |
| Malic Acid SCHEMBL2467748 | 0.81 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1TP53 | |
| Malic Acid SCHEMBL28852027 | 0.80 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1TP53 | |
| SCHEMBL31173032 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013032190-A1 | PHOTOPOLYMERIZABLE UNSATURATED RESIN, PHOTOSENSITIVE RESIN COMPOSITION COMPRISING THE SAME, AND LIGHT SHIELDING SPACER AND LIQUID CRYSTAL DISPLAY DEVICE FORMED THEREFROM | ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) | 2013-03-07 | — | — | WO | claimed |