Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.57 |
| ▸ | FAP | Q12884 | 4/20 | 0.57 |
| ▸ | CCR1 | P32246 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18457263 | 0.89 | PREP (0.57) | PREPFAPCCR1CTSBNSD2 | |
| SCHEMBL18416081 | 0.87 | PREP (0.56) | PREPFAPCCR1CTSBNSD2 | |
| SCHEMBL10118999 | 0.87 | CTSB (0.67) | PREPFAPCCR1CTSBNSD2 | |
| SCHEMBL18457261 | 0.85 | PREP (0.54) | PREPFAPCCR1CTSBNSD2 | |
| SCHEMBL14316520 | 0.81 | PREP (0.46) | PREPFAPCCR1CTSBCTSV | |
| SCHEMBL18416076 | 0.80 | PREP (0.57) | PREPFAPCCR1MEN1KMT2A | |
| SCHEMBL18457550 | 0.80 | TACR3 (0.65) | PREPFAPMEN1KMT2ATACR3 | |
| SCHEMBL22345511 | 0.79 | CCR1 (0.53) | CCR1BBOX1EGLN1FTOMEN1 | |
| SCHEMBL22345508 | 0.79 | CCR1 (0.53) | CCR1BBOX1EGLN1FTOMEN1 | |
| Iodide SCHEMBL22345354 | 0.79 | BBOX1 (0.43) | PREPFAPKDM4CBBOX1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033396-A2 | FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS | TRUSTEES OF TUFTS COLLEGE (US) | 2013-03-07 | — | — | WO | disclosed |