Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637528 | 0.92 | KCNH2 (0.56) | KCNH2SCN3AMEN1KMT2AALDH1A1 | |
| SCHEMBL4637526 | 0.92 | KCNH2 (0.56) | KCNH2SCN3AMEN1KMT2AALDH1A1 | |
| SCHEMBL3585032 | 0.92 | KCNH2 (0.56) | KCNH2SCN3AMEN1KMT2AALDH1A1 | |
| SCHEMBL2350627 | 0.92 | KCNH2 (0.56) | KCNH2SCN3AMEN1KMT2AALDH1A1 | |
| SCHEMBL3585037 | 0.92 | KCNH2 (0.56) | KCNH2SCN3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8258775 | 0.87 | KCNH2 (0.41) | KCNH2SCN3ATSHRMEN1KMT2A | |
| SCHEMBL27771931 | 0.85 | KCNH2 (0.51) | KCNH2SCN3A | |
| SCHEMBL4089338 | 0.79 | KCNH2 (0.52) | KCNH2SCN3AALDH1A1 | |
| SCHEMBL2346176 | 0.78 | MEN1 (0.47) | KCNH2SCN3ATSHRMEN1KMT2A | |
| SCHEMBL28908009 | 0.78 | KCNH2 (0.41) | KCNH2SCN3AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033310-A1 | MODULATORS OF REV-ERB | KAMENECKA THEODORE MARK (US) | 2013-03-07 | — | — | WO | disclosed |