Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740751 | 0.84 | MEN1 (0.47) | KMT2AMEN1CTDSP1NPC1RAB9A | |
| SCHEMBL14740818 | 0.78 | STING1 (0.42) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL17336575 | 0.75 | RAB9A (0.43) | KMT2AMEN1CTDSP1NPC1RAB9A | |
| SCHEMBL14053110 | 0.74 | ALDH1A1 (0.47) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL18064949 | 0.68 | MCL1 (0.73) | KMT2AMEN1CTDSP1NPC1RAB9A | |
| SCHEMBL1321794 | 0.68 | KDM4E (0.61) | KMT2ANPC1RAB9AKDM4ELMNA | |
| SCHEMBL16407456 | 0.66 | AAK1 (0.39) | ALDH1A1 | |
| SCHEMBL14740851 | 0.65 | MAPT (0.37) | KMT2AMEN1RAB9AKDM4EGAA | |
| SCHEMBL14740755 | 0.64 | ALDH1A1 (0.37) | KMT2AMEN1CTDSP1NPC1KDM4E | |
| SCHEMBL23354039 | 0.64 | KDM4E (0.55) | KMT2AMEN1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751095-A2 | NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF | Sanford-Burnham Medical Research Institute (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033246-A2 | NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF | BRAINCELLS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |