Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11276543 | 0.87 | CDC25B (0.52) | MAPTCDC25BTSHRHCAR3KMT2A | |
| SCHEMBL2656516 | 0.83 | POLB (0.50) | MAPTTSHRKMT2AMEN1KDM4E | |
| SCHEMBL9793680 | 0.83 | POLB (0.50) | MAPTTSHRKMT2AMEN1KDM4E | |
| SCHEMBL1497989 | 0.81 | TSHR (0.60) | MAPTTSHRKMT2AMEN1KDM4E | |
| SCHEMBL28171346 | 0.79 | TSHR (0.58) | MAPTTSHRKMT2AMEN1KDM4E | |
| SCHEMBL27771692 | 0.79 | TSHR (0.58) | MAPTTSHRKMT2AMEN1KDM4E | |
| SCHEMBL30490414 | 0.79 | TSHR (0.58) | MAPTTSHRKMT2AMEN1KDM4E | |
| Ethylene SCHEMBL29290025 | 0.77 | TSHR (0.56) | MAPTTSHRKMT2AMEN1KDM4E | |
| SCHEMBL31110244 | 0.77 | HCAR3 (0.55) | MAPTTSHRHCAR3KMT2AMEN1 | |
| SCHEMBL940162 | 0.77 | ALB (0.55) | MAPTTSHRKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9453051-B2 | Cyclosporin derivatives | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2016-09-27 | — | — | US | disclosed |
| EP-2751127-B1 | CYCLOSPORIN DERIVATIVES | MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V (DE) | 2016-07-27 | — | — | EP | disclosed |
| US-20140316104-A1 | CYCLOSPORIN DERIVATIVES | LEAD DISCOVER CENTER GMBH (DE) | 2014-10-23 | — | — | US | disclosed |
| EP-2751127-A1 | CYCLOSPORIN DERIVATIVES | Max-Planck-Gesellschaft zur Förderung der Wissenschaften (DE) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013030208-A1 | CYCLOSPORIN DERIVATIVES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140316104-A1 | CYCLOSPORIN DERIVATIVES | CHP1, RYR2, CANX | MAPT 1585/4885CDC25B 920/4885TSHR 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.