Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 1/20 | 0.48 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.45 |
| ▸ | RHOC | P08134 | 6/20 | 0.45 |
| ▸ | RHOA | P61586 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743066 | 0.86 | KMT2A (0.47) | P2RX1ALDH1A1MEN1KMT2A | |
| SCHEMBL14744258 | 0.86 | KMT2A (0.47) | P2RX1ALDH1A1MEN1KMT2A | |
| SCHEMBL14743338 | 0.86 | KMT2A (0.47) | P2RX1ALDH1A1MEN1KMT2A | |
| SCHEMBL14743056 | 0.85 | KMT2A (0.49) | ALDH1A1HPGDL3MBTL1EPHX2NLRP3 | |
| SCHEMBL14743396 | 0.81 | ADORA3 (0.51) | ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL14743511 | 0.81 | MAPT (0.47) | TMPRSS4ALDH1A1NLRP3MEN1POLB | |
| SCHEMBL14743584 | 0.81 | ADORA3 (0.51) | ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL14743391 | 0.81 | MEN1 (0.57) | KCNJ5KCNJ3ALDH1A1HPGDGRIK1 | |
| SCHEMBL29475999 | 0.77 | GRIN2B (0.43) | ALDH1A1MEN1KMT2A | |
| SCHEMBL14743029 | 0.76 | GRIK1 (0.44) | ALDH1A1GRIK1L3MBTL1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758370-A1 | PARP INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-30 | — | — | EP | claimed |
| WO-2013030205-A1 | PARP INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | claimed |
| EP-2758370-A1 | PARP INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013030205-A1 | PARP INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |