Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743066 | 1.00 | KMT2A (0.47) | KMT2AMEN1ALDH1A1MAOAMAOB | |
| SCHEMBL14743338 | 1.00 | KMT2A (0.47) | KMT2AMEN1ALDH1A1MAOAMAOB | |
| SCHEMBL14743391 | 0.89 | MEN1 (0.57) | KMT2AMEN1ALDH1A1RAB9ALMNA | |
| SCHEMBL14743449 | 0.86 | KCNJ5 (0.48) | KMT2AMEN1ALDH1A1P2RX1 | |
| SCHEMBL14757460 | 0.85 | MEN1 (0.47) | KMT2AMEN1ALDH1A1MAOAMAOB | |
| SCHEMBL14757451 | 0.85 | MEN1 (0.47) | KMT2AMEN1ALDH1A1MAOAMAOB | |
| SCHEMBL14743396 | 0.84 | ADORA3 (0.51) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL14743511 | 0.84 | MAPT (0.47) | KMT2AMEN1ALDH1A1MAOBIDO1 | |
| SCHEMBL14743584 | 0.84 | ADORA3 (0.51) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL14743056 | 0.83 | KMT2A (0.49) | KMT2AMEN1ALDH1A1TP53CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758370-A1 | PARP INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-30 | — | — | EP | claimed |
| WO-2013030205-A1 | PARP INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | claimed |
| EP-2758370-A1 | PARP INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013030205-A1 | PARP INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |