Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14757450 | 0.86 | EPHX2 (0.52) | EPHX2EPHX1ALDH1A1KMT2ARAB9A | |
| SCHEMBL14744256 | 0.76 | EPHX2 (0.55) | EPHX2EPHX1ALDH1A1KMT2ARAB9A | |
| SCHEMBL14743178 | 0.74 | EPHX2 (0.53) | EPHX2EPHX1ALDH1A1KMT2AGAA | |
| SCHEMBL1224206 | 0.74 | TRPM5 (0.50) | ALDH1A1KMT2AL3MBTL1HPGDPOLB | |
| SCHEMBL12196177 | 0.73 | EPHX1 (1.00) | EPHX2EPHX1ALDH1A1KMT2ARAB9A | |
| SCHEMBL5123721 | 0.72 | CHRM1 (0.57) | EPHX2KMT2ARAB9AL3MBTL1NPC1 | |
| SCHEMBL11704653 | 0.70 | POLB (0.62) | ALDH1A1KMT2ARAB9AL3MBTL1NPC1 | |
| SCHEMBL29213228 | 0.70 | ERCC1 (0.56) | ALDH1A1KMT2AGAAL3MBTL1HPGD | |
| SCHEMBL1197606 | 0.70 | APEX1 (0.64) | ALDH1A1KMT2ARAB9AL3MBTL1MEN1 | |
| SCHEMBL23322559 | 0.69 | PTGIR (0.71) | EPHX2EPHX1ALDH1A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758370-A1 | PARP INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013030205-A1 | PARP INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |