SCHEMBL14744256

SCHEMBL14744256

O=C(C[S+]([O-])c1cccc(Cl)c1)NCC1CCCCC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 3/20 0.55
EPHX1 P07099 1/20 0.55
ALDH1A1 P00352 3/20 0.47
GAA P10253 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
NPC1 O15118 3/20 0.46
POLB P06746 2/20 0.46
FBP1 P09467 1/20 0.43
KMT2A Q03164 4/20 0.43
MEN1 O00255 2/20 0.43
CNR2 P34972 2/20 0.42
CNR1 P21554 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
RAB9A P51151 2/20 0.41
CTSD P07339 1/20 0.41
BACE1 P56817 1/20 0.41
KCNH2 Q12809 1/20 0.41
BACE2 Q9Y5Z0 1/20 0.41
TSHR P16473 1/20 0.41
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14743178 0.99 EPHX2 (0.53) EPHX2EPHX1ALDH1A1GAAL3MBTL1
SCHEMBL14743089 0.83 EPHX2 (0.61) EPHX2EPHX1ALDH1A1L3MBTL1NPC1
SCHEMBL14743505 0.76 EPHX2 (0.57) EPHX2EPHX1ALDH1A1GAAL3MBTL1
SCHEMBL14743775 0.72 ERCC5 (0.42) ALDH1A1NPC1KMT2AMEN1SMN1; SMN2
SCHEMBL12196177 0.71 EPHX1 (1.00) EPHX2EPHX1ALDH1A1NPC1POLB
SCHEMBL23322559 0.70 PTGIR (0.71) EPHX2EPHX1ALDH1A1GAAL3MBTL1
SCHEMBL14743917 0.70 KMT2A (0.44) ALDH1A1NPC1KMT2AMEN1RAB9A
SCHEMBL14743512 0.70 KMT2A (0.64) ALDH1A1L3MBTL1NPC1POLBKMT2A
SCHEMBL14744258 0.69 KMT2A (0.47) ALDH1A1GAAKMT2AMEN1CNR1
SCHEMBL14743338 0.69 KMT2A (0.47) ALDH1A1GAAKMT2AMEN1CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2758370-A1 PARP INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-07-30 EP claimed
WO-2013030205-A1 PARP INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-07 WO claimed
EP-2758370-A1 PARP INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-07-30 EP disclosed
WO-2013030205-A1 PARP INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-07 WO disclosed