Coumarin

Coumarin

SCHEMBL14744008

NC(=O)c1ccccc1.O=c1ccc2ccccc2o1

nearest known ligand 0.67

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 6/20 0.67
CA9 Q16790 6/20 0.67
TDP1 Q9NUW8 3/20 0.67
CA1 P00915 3/20 0.67
CA2 P00918 2/20 0.67
CA3 P07451 2/20 0.67
CA4 P22748 2/20 0.67
CA5A P35218 2/20 0.67
CA7 P43166 2/20 0.67
CA14 Q9ULX7 2/20 0.67
CA5B Q9Y2D0 2/20 0.67
MCL1 Q07820 2/20 0.67
LMNA P02545 1/20 0.67
CA6 P23280 1/20 0.67
SOST Q9BQB4 1/20 0.67
POLB P06746 2/20 0.53
TSHR P16473 2/20 0.53
MAPT P10636 2/20 0.53
HSD17B10 Q99714 2/20 0.53
CYP3A4 P08684 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Coumarin SCHEMBL23929067 0.90 CA12 (0.77) CA12CA9TDP1CA1CA2
Benzophenone SCHEMBL27755446 0.86 CA12 (0.71) CA12CA9TDP1CA1CA2
Coumarin SCHEMBL1090505 0.86 CA12 (0.83) CA12CA9TDP1CA1CA2
Coumarin SCHEMBL25431834 0.86 CA12 (0.91) CA12CA9TDP1CA1CA2
Umbelliferone SCHEMBL17063687 0.84 CA12 (0.68) CA12CA9TDP1CA1CA2
Coumarin SCHEMBL28089700 0.84 F7 (0.59) CA12CA9TDP1CA1CA2
Coumarin SCHEMBL28423147 0.84 CA12 (0.95) CA12CA9TDP1CA1CA2
Coumarin SCHEMBL19183240 0.84 CA12 (0.95) CA12CA9TDP1CA1CA2
SCHEMBL7358531 0.84 CA12 (0.95) CA12CA9TDP1CA1CA2
Coumarin SCHEMBL29078087 0.82 CA12 (0.77) CA12CA9TDP1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013029075-A1 MEANS AND METHOD FOR ALKYLATION TECHNISCHE UNIVERSITÄT GRAZ (AT) 2013-03-07 WO disclosed