Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAN2B1 | O00754 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737595 | 1.00 | HTT (0.43) | HTTNPSR1ALDH1A1GFEREPHX1 | |
| SCHEMBL3583570 | 0.87 | L3MBTL1 (0.39) | HTTNPSR1GFEREPHX1MAN2B1 | |
| SCHEMBL28230784 | 0.83 | HTT (0.45) | HTTNPSR1ALDH1A1GFEREPHX1 | |
| SCHEMBL12299216 | 0.79 | MEN1 (0.39) | HTTNPSR1ALDH1A1GFEREPHX1 | |
| SCHEMBL18764623 | 0.78 | HTT (0.43) | HTTNPSR1ALDH1A1GFEREPHX1 | |
| SCHEMBL18764829 | 0.78 | HTT (0.45) | HTTNPSR1ALDH1A1GFEREPHX1 | |
| SCHEMBL30322973 | 0.75 | PEPD (0.35) | LMNA | |
| SCHEMBL28231758 | 0.74 | HTT (0.46) | HTTNPSR1ALDH1A1GFEREPHX1 | |
| SCHEMBL18792409 | 0.73 | MIF (0.31) | — | |
| SCHEMBL30562984 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |