Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 5/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744075 | 0.86 | PIK3CD (0.43) | PIK3CDPIK3R1PIK3CGPIK3R2ABCB11 | |
| SCHEMBL14743894 | 0.85 | PIK3CD (0.42) | PIK3CDPIK3R1PIK3CGPIK3R2ABCB11 | |
| SCHEMBL935877 | 0.82 | PIK3CD (0.41) | PIK3CDPIK3R1PIK3CGPIK3R2PIK3CB | |
| SCHEMBL15820628 | 0.81 | PIK3CD (0.53) | PIK3CDPIK3R1PIK3CGPIK3R2PIK3CA | |
| SCHEMBL14718673 | 0.81 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CGPIK3R2ABCB11 | |
| SCHEMBL14718674 | 0.81 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CGPIK3R2ABCB11 | |
| SCHEMBL935671 | 0.75 | PIK3CD (0.51) | PIK3CDPIK3R1PIK3CGABCB11TBXA2R | |
| SCHEMBL14729932 | 0.75 | PIK3CD (0.58) | PIK3CDPIK3R1PIK3CGPIK3R2PIK3CA | |
| SCHEMBL17262981 | 0.74 | PIK3CB (0.47) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL17235373 | 0.73 | PIK3CD (0.73) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751093-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Infinity Pharmaceuticals, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013032591-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS INC. (US) | 2013-03-07 | — | — | WO | disclosed |