SCHEMBL14744325

SCHEMBL14744325

CCS(=O)(=O)c1ccc(CC(=O)Nc2cnc(Cl)nc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.68
RORB Q92753 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17187026 0.82 RORC (0.60) RORC
SCHEMBL24759683 0.79 RORC (0.89) RORC
SCHEMBL18151482 0.78 RORC (0.73) RORC
SCHEMBL14744339 0.78 RORC (0.71) RORC
SCHEMBL18156957 0.77 RORC (0.65) RORC
SCHEMBL24608352 0.77 RORC (0.61) RORC
SCHEMBL24608634 0.77 RORC (0.54) RORC
SCHEMBL29700922 0.77 RORC (0.61) RORC
SCHEMBL23174348 0.77 RORC (0.89) RORC
SCHEMBL21616659 0.77 RORC (0.67) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112513021-B ROR gamma antagonist and application thereof in medicines 广东东阳光药业有限公司 2023-06-27 CN disclosed
CN-112513021-A ROR gamma antagonist and application thereof in medicine 广东东阳光药业有限公司 2021-03-16 CN disclosed
WO-2013029338-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2013-03-07 WO disclosed