Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 5/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744269 | 0.88 | PARP1 (0.39) | AURKAPDPK1AURKB | |
| SCHEMBL14744385 | 0.84 | MAPT (0.33) | DGAT1 | |
| SCHEMBL14743918 | 0.82 | DGAT1 (0.34) | DGAT1 | |
| SCHEMBL14738230 | 0.82 | SYK (0.43) | JAK1JAK2KAT8DGAT1 | |
| SCHEMBL14744517 | 0.79 | SYK (0.42) | DGAT1 | |
| SCHEMBL14737214 | 0.78 | SYK (0.51) | JAK1JAK2 | |
| SCHEMBL14737213 | 0.78 | SYK (0.51) | JAK1JAK2 | |
| SCHEMBL14744289 | 0.77 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL18524473 | 0.76 | SYK (0.43) | JAK1JAK2PLK1 | |
| SCHEMBL14738580 | 0.76 | SYK (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |