Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743918 | 0.90 | DGAT1 (0.34) | MAPTMAPK1DGAT1 | |
| SCHEMBL14744226 | 0.86 | SYK (0.34) | MAPTMAPK1DGAT1SYK | |
| SCHEMBL14744327 | 0.84 | AURKA (0.35) | DGAT1 | |
| SCHEMBL14737439 | 0.84 | MAPK1 (0.32) | MAPTTRPA1MAPK1DGAT1SYK | |
| SCHEMBL14744517 | 0.83 | SYK (0.42) | MAPTMAPK1DGAT1SYK | |
| SCHEMBL14744269 | 0.83 | PARP1 (0.39) | MAPK1 | |
| SCHEMBL14744289 | 0.82 | DGAT1 (0.33) | MAPTDGAT1SYK | |
| SCHEMBL14743741 | 0.82 | KLKB1 (0.33) | MAPTMAPK1DGAT1SYK | |
| SCHEMBL14747034 | 0.82 | PDE4A (0.37) | MAPTMAPK1ALDH1A1 | |
| SCHEMBL14738342 | 0.82 | SYK (0.43) | MAPTMAPK1DGAT1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |