Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 15/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24424912 | 0.76 | CACNA1H (0.40) | DGAT1 | |
| Hydrochloric Acid SCHEMBL14744363 | 0.73 | CACNA1H (0.40) | MAOB | |
| SCHEMBL4765262 | 0.73 | HTT (0.40) | MAOB | |
| SCHEMBL19116691 | 0.72 | DGAT1 (0.35) | DGAT1KMT2A | |
| SCHEMBL14738097 | 0.70 | DGAT1 (0.37) | DGAT1KMT2A | |
| SCHEMBL31373920 | 0.69 | TSHR (0.37) | DGAT1SCN10A | |
| SCHEMBL18255655 | 0.68 | PKM (0.38) | DGAT1SCN10A | |
| SCHEMBL30889704 | 0.67 | NOTUM (0.42) | DGAT1 | |
| SCHEMBL11358551 | 0.67 | ESR1 (0.41) | — | |
| SCHEMBL23374481 | 0.66 | MAOB (0.40) | MAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |