Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16394950 | 0.85 | RAB9A (0.59) | ALDH1A1SMN1; SMN2RAB9ANPC1GRM2 | |
| SCHEMBL1420797 | 0.82 | ALDH1A1 (1.00) | ALDH1A1TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14744648 | 0.82 | GRM2 (0.64) | ALDH1A1SMN1; SMN2RAB9ANPC1GRM2 | |
| SCHEMBL14744633 | 0.82 | GRM2 (0.66) | ALDH1A1SMN1; SMN2RAB9ANPC1GRM2 | |
| SCHEMBL14744793 | 0.82 | GRM2 (0.52) | ALDH1A1SMN1; SMN2RAB9AGRM2 | |
| SCHEMBL23954519 | 0.82 | RAB9A (0.69) | ALDH1A1SMN1; SMN2RAB9ANPC1GRM2 | |
| SCHEMBL14744721 | 0.82 | RAB9A (0.49) | SMN1; SMN2RAB9AGRM2 | |
| SCHEMBL14744704 | 0.82 | GRM2 (0.55) | ALDH1A1SMN1; SMN2RAB9ANPC1GRM2 | |
| SCHEMBL14744661 | 0.82 | RAB9A (0.49) | ALDH1A1SMN1; SMN2RAB9ANPC1GRM2 | |
| SCHEMBL16395290 | 0.81 | GRM2 (0.54) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751095-A2 | NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF | Sanford-Burnham Medical Research Institute (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033246-A2 | NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF | BRAINCELLS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |