Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745626 | 0.92 | ALDH1A1 (0.41) | MEN1KMT2ANPY5RALDH1A1SMN1; SMN2 | |
| SCHEMBL14747045 | 0.91 | KMT2A (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14745363 | 0.91 | MEN1 (0.36) | MEN1KMT2ANPY5RALDH1A1SMN1; SMN2 | |
| SCHEMBL17594964 | 0.83 | ALDH1A1 (0.35) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14745564 | 0.82 | KIF11 (0.42) | MEN1KMT2ANPY5RALDH1A1SMN1; SMN2 | |
| SCHEMBL14741215 | 0.82 | KDM4E (0.39) | GAAKDM4E | |
| SCHEMBL14744987 | 0.82 | ALDH1A1 (0.37) | MEN1KMT2ANPY5RALDH1A1SMN1; SMN2 | |
| SCHEMBL14747044 | 0.81 | KIF11 (0.41) | MEN1KMT2ANPY5RALDH1A1SMN1; SMN2 | |
| SCHEMBL14744809 | 0.81 | ALDH1A1 (0.36) | MEN1KMT2ANPY5RALDH1A1SMN1; SMN2 | |
| SCHEMBL14745174 | 0.79 | KCNH2 (0.40) | MEN1KMT2ANPY5RALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |
| EP-2750505-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033240-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |