Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 5/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL151349 | 0.85 | ALDH1A1 (0.47) | ALDH1A1ALOX15MAPK1CASP1CASP7 | |
| SCHEMBL147457 | 0.69 | ALOX15 (0.49) | ALDH1A1ALOX15MAPK1CASP1CASP7 | |
| SCHEMBL1877502 | 0.68 | ALDH1A1 (0.71) | ALDH1A1ALOX15MAPK1CASP1CASP7 | |
| SCHEMBL29785257 | 0.68 | ALDH1A1 (0.64) | ALDH1A1ALOX15MAPK1CASP1CASP7 | |
| SCHEMBL145735 | 0.67 | ALDH1A1 (0.57) | ALDH1A1ALOX15MAPK1CASP1CASP7 | |
| SCHEMBL19279345 | 0.66 | ALOX15 (0.50) | ALDH1A1ALOX15MAPK1CASP1CASP7 | |
| SCHEMBL3697229 | 0.66 | JAK2 (0.59) | PARP1BTK | |
| SCHEMBL5621893 | 0.65 | PARP1 (0.67) | PARP1PARP2 | |
| SCHEMBL16266107 | 0.65 | ALDH1A1 (1.00) | ALDH1A1ALOX15MAPK1CASP1CASP7 | |
| SCHEMBL31328323 | 0.64 | ALOX15 (0.64) | ALDH1A1ALOX15MAPK1CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391602-B1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2013-12-04 | — | — | EP | disclosed |
| US-8362065-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
| US-8084620-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | ALDH1A1 3832/4885ALOX15 4154/4885MAPK1 239/4885 |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | ALDH1A1 3832/4885ALOX15 4154/4885MAPK1 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.