Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735979 | 0.83 | GLRA1 (0.41) | PIK3CDALDH1A1 | |
| SCHEMBL14742564 | 0.81 | MAOB (0.40) | DRD2DRD4DRD3S1PR5S1PR1 | |
| SCHEMBL14742228 | 0.81 | DRD2 (0.37) | DRD2DRD4DRD3L3MBTL1S1PR5 | |
| SCHEMBL19156667 | 0.77 | MEN1 (0.36) | PIK3CDLMNAALDH1A1HTT | |
| SCHEMBL9929491 | 0.74 | PIK3CD (0.39) | PIK3CDALDH1A1DPP4 | |
| Hydrochloric Acid SCHEMBL9928983 | 0.74 | PIK3CD (0.39) | PIK3CDALDH1A1DPP4 | |
| SCHEMBL19157185 | 0.71 | PIK3CD (0.43) | PIK3CDDPP4HTT | |
| SCHEMBL23877386 | 0.67 | POLB (0.33) | LMNAALDH1A1TSHRHTT | |
| SCHEMBL14735921 | 0.67 | THRB (0.37) | PIK3CDLMNAALDH1A1TSHRHTT | |
| SCHEMBL29689131 | 0.67 | POLB (0.33) | LMNAALDH1A1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | disclosed |