Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.70 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747809 | 0.90 | PTGS2 (0.71) | PTGS2PTGS1POLB | |
| SCHEMBL14747603 | 0.84 | PTGS2 (0.55) | PTGS2PTGS1F10POLBRAB9A | |
| SCHEMBL6342810 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL14747606 | 0.81 | PTGS2 (0.51) | PTGS2PTGS1F10POLBMEN1 | |
| SCHEMBL14747605 | 0.80 | PTGS2 (0.48) | PTGS2PTGS1F10POLB | |
| SCHEMBL8631459 | 0.76 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL8638095 | 0.75 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL14747815 | 0.73 | PTGS2 (0.54) | PTGS2PTGS1POLBALDH1A1RAB9A | |
| SCHEMBL8689482 | 0.72 | PTGS2 (0.67) | PTGS2PTGS1F10 | |
| SCHEMBL28724936 | 0.72 | MAPT (0.46) | PTGS2PTGS1F10POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44048-E1 | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-YL]benzenesulfonamide for the treatment of inflammation or an inflammation-associated disorder | G.D. SEARLE LLC (US) | 2013-03-05 | — | — | US | disclosed |