Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.67 |
| ▸ | F10 | P00742 | 5/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637646 | 0.91 | PTGS2 (0.56) | PTGS2PTGS1F10 | |
| SCHEMBL8693434 | 0.86 | PTGS2 (0.53) | PTGS2PTGS1F10CA12CA1 | |
| SCHEMBL8691651 | 0.85 | PTGS2 (0.49) | PTGS2PTGS1F10CA12CA1 | |
| SCHEMBL8689175 | 0.83 | F10 (0.49) | PTGS2PTGS1F10 | |
| SCHEMBL8689128 | 0.83 | PTGS2 (0.47) | PTGS2PTGS1F10CA12CA1 | |
| SCHEMBL8688474 | 0.83 | PTGS2 (0.47) | PTGS2PTGS1F10CA12CA1 | |
| SCHEMBL8692071 | 0.83 | PTGS2 (0.69) | PTGS2PTGS1F10CA12CA1 | |
| SCHEMBL8691301 | 0.83 | PTGS2 (0.47) | PTGS2PTGS1F10CA12CA1 | |
| SCHEMBL8689419 | 0.83 | PTGS2 (0.47) | PTGS2PTGS1F10CA12CA1 | |
| SCHEMBL8688630 | 0.83 | PTGS2 (0.55) | PTGS2PTGS1F10CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |