Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7636421 | 0.89 | REN (0.53) | RENTSHRNPSR1CYP3A4CYP2C19 | |
| SCHEMBL14747751 | 0.87 | REN (0.42) | RENTSHRNPSR1ALDH1A1THRB | |
| SCHEMBL5987076 | 0.86 | REN (0.49) | RENTSHRNPSR1CYP3A4CYP2C19 | |
| SCHEMBL5986192 | 0.84 | REN (0.48) | RENTSHRNPSR1CYP3A4CYP2C19 | |
| SCHEMBL7634836 | 0.84 | REN (0.48) | RENTSHRNPSR1CYP3A4CYP2C19 | |
| SCHEMBL5985048 | 0.84 | REN (0.48) | RENTSHRNPSR1CYP3A4CYP2C19 | |
| SCHEMBL14747753 | 0.81 | CYP2C19 (0.42) | RENTSHRNPSR1CYP3A4CYP2C19 | |
| SCHEMBL5985698 | 0.81 | REN (0.46) | RENTSHRNPSR1CYP3A4CYP2C19 | |
| SCHEMBL5987063 | 0.81 | REN (0.46) | RENTSHRNPSR1CYP3A4CYP2C19 | |
| SCHEMBL13434135 | 0.79 | TSHR (0.59) | RENTSHRNPSR1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389511-B2 | Bicyclic heterocyclic derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-03-05 | — | — | US | disclosed |